The mission of Discovering Dengue Drugs – Together is to discover promising drug leads that stop the replication of viruses within the Flaviviridae family. Diseases caused by Flaviviridae include:
- Dengue
- Hepatitis C
- West Nile
- Yellow fever
The project has been extended to include leishmaniasis.
The approach used by the project is to develop drugs that inhibit the viral NS3 protease. The NS3 protease is an enzyme critical for virus replication, and its amino acid sequence and atomic structure are very similar among the different disease–causing flaviviruses. The researchers are using AutoDock to find compounds that bind strongly with NS3.
Publications[]
- Main article: Publications
Tomlinson, S. M.; Malmstrom, R. D.; Watowich, S. J. (2009),
"New Approaches to Structure-Based Discovery of Dengue Protease Inhibitors",
Infect Disord Drug Targets 9 (3): 327 - 343, doi:
External links[]
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Discovering Dengue Drugs - Together
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Status
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Complete
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Info
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Phase 1 complete
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August 21, 2007
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Completion date
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August 26, 2009
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Research software
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Software version
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6.06
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Project news
[:)][:)] Join "MyOnlineTeam" Today - Chapter 75[:)][:)] - - 1970/01/01 00:00
- [img]myonlineteam.org/images/headers/header01.png[/img] [b]Welcome to the World Community Grid team thread for MyOnlineTeam! We would love to have you as a member![/b] [u][b]What are we?[/b][/u] My...
What's the highest batch you have received? (MCM1) - - 1970/01/01 00:00
- I thought we should have a "What's the highest batch you have received?" thread for MCM1 also, and not only for OPN1 and OPNG. I'll begin with my highest batch as of now: [s]MCM1_0197448[/s] MCM1_01...
Comprehensive Issue List & Report Thread (Feb. 24, 2023) - - 1970/01/01 00:00
- Hi everyone, this thread aims to list all of the issues (past and present, resolved or not) that we have been made aware of and exist as the main thread to report new issues. To keep the forums organ...
What's the highest batch you have received (GPU OPNG ONLY)? - - 1970/01/01 00:00
- Hi all fellow crunchers! We need a way to track batches received for GPU work as well, so here we can report the highest batch received for GPU WUs (WUs starting with OPNG in the name). I'll start wi...
Ukraine - Украина - Україна - - 1970/01/01 00:00
- Украинцы! А также украиноговорящие жители других стран кто хочет поддержать украинскую команду! [img]http://upload.wikimedia.org/wikipedia/commons/thumb/4/49/Flag_of_Ukraine.svg/125px-Flag_of_Ukraine...
Known issues
[:)][:)] Join "MyOnlineTeam" Today - Chapter 75[:)][:)] - - 1970/01/01 00:00
- [img]myonlineteam.org/images/headers/header01.png[/img] [b]Welcome to the World Community Grid team thread for MyOnlineTeam! We would love to have you as a member![/b] [u][b]What are we?[/b][/u] My...
What's the highest batch you have received? (MCM1) - - 1970/01/01 00:00
- I thought we should have a "What's the highest batch you have received?" thread for MCM1 also, and not only for OPN1 and OPNG. I'll begin with my highest batch as of now: [s]MCM1_0197448[/s] MCM1_01...
Comprehensive Issue List & Report Thread (Feb. 24, 2023) - - 1970/01/01 00:00
- Hi everyone, this thread aims to list all of the issues (past and present, resolved or not) that we have been made aware of and exist as the main thread to report new issues. To keep the forums organ...
What's the highest batch you have received (GPU OPNG ONLY)? - - 1970/01/01 00:00
- Hi all fellow crunchers! We need a way to track batches received for GPU work as well, so here we can report the highest batch received for GPU WUs (WUs starting with OPNG in the name). I'll start wi...
Ukraine - Украина - Україна - - 1970/01/01 00:00
- Украинцы! А также украиноговорящие жители других стран кто хочет поддержать украинскую команду! [img]http://upload.wikimedia.org/wikipedia/commons/thumb/4/49/Flag_of_Ukraine.svg/125px-Flag_of_Ukraine...
Screensaver screenshot